A statement on United's website on Monday said Rooney's ankle injury "is not thought to be serious.
Manchester: Manchester United says Wayne Rooney will miss Wednesday's Champions League match against Valencia because of an ankle injury.
The England striker was substituted in the 61st minute of United's 2-2 draw at Bolton on Sunday and the Premier League club says he will not be part of the squad that flies to Spain on Tuesday.
A statement on United's website on Monday said Rooney's ankle injury "is not thought to be serious," but added that Ferguson has chosen not to play him against the Spanish leaders.
United, which drew 0-0 with Rangers in its opening Group C match, is already without injured wingers Ryan Giggs and Antonio Valencia.
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